Mercedes-Benz C250 PO303 misfire in cylinders 2 and 3 with non-engine light on on Mercedes-Benz C250

Submitted by Vehicle Owner · Jun 23, 2025
Published by RepairPal

Problem overview

Some Mercedes-Benz C250 owners report experiencing diagnostic trouble code P0303, indicating a misfire in cylinder 3, which can lead to issues such as lack of power, rough idling, increased emissions, and potential damage to the catalytic converter. Additionally, those encountering misfires in both cylinders 2 and 3 may face a broader issue affecting multiple cylinders. Common causes for these misfires include worn or damaged spark plugs and ignition coils, which should be checked and replaced if necessary. Owners are also advised to inspect fuel injectors and compression levels in the affected cylinders. Given that the misfire impacts multiple cylinders, assessing the overall health of the ignition and fuel systems, along with engine components, is crucial. Some owners find it helpful to swap ignition coils between cylinders to determine if the issue follows the component, aiding in pinpointing the source of the misfire.

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